Esterase activity of cyclodextrin dithiocarbamates

被引：14
|
作者：
Fragoso, A [1 ]
Cao, R [1 ]
Baños, M [1 ]
机构：
[1] Univ Havana, Fac Chem, Lab Bioinorgan Chem, Havana, Cuba
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 21期
关键词：
cyclodextrin; dithiocarbamate; esterase activity; copper;
D O I：
10.1016/j.tetlet.2004.03.156
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The catalytic activity of dithiocarbamate appended alpha- and beta-cyclodextrins in the hydrolysis of p-nitrophenyl acetate (PNPA) vas studied at alkaline pH. The values of k(cat)/k(uncat) for the hydrolysis of PNPA ranged from 8 to 165 in the presence of the catalyst and are pH independent in the range 7.5-9.0. Addition of Cu(II) increases the activity by factors of 75-515 and k(cat) values increase with increasing pH in the same range. The differences in the obtained kinetic parameters are interpreted on the basis of two different mechanisms. (C) 2004 Elsevier Ltd. All rights reserved.
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页码：4069 / 4071
页数：3
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