Biomarkers of lupus nephritis histology and flare: deciphering the relevant amidst the noise

被引：47
|
作者：
Birmingham, Daniel J. [1 ]
Merchant, Michael [2 ]
Waikar, Sushrut S. [3 ]
Nagaraja, Haikady [4 ]
Klein, Jon B. [2 ]
Rovin, Brad H. [1 ]
机构：
[1] Ohio State Univ, Wexner Med Ctr, Div Nephrol, 395 West 12th Ave,Ground Floor, Columbus, OH 43210 USA
[2] Univ Louisville, Sch Med, Louisville, KY 40292 USA
[3] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA
[4] Ohio State Univ, Coll Publ Hlth, Columbus, OH 43210 USA
来源：
NEPHROLOGY DIALYSIS TRANSPLANTATION | 2017年 / 32卷
基金：
美国国家卫生研究院;
关键词：
discovery and validation; longitudinal cohort; urine analyte; ERYTHROCYTE COMPLEMENT RECEPTORS; LABORATORY TESTS; URINE BIOMARKERS; ACTIVITY INDEX; RENAL FLARE; ERYTHEMATOSUS; KIDNEY; CR-1; INFLAMMATION; DISEASE;
D O I：
10.1093/ndt/gfw300
中图分类号：
R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ;
摘要：
Biomarker development in lupus nephritis (LN) has traditionally relied on comparing the characteristics of candidate markers to clinical findings in patients and controls from cross-sectional cohorts. In this work, two additional strategies for LN biomarker development that are gaining ground will be discussed. One approach compares analytes directly to kidney histology. The second strategy utilizes longitudinal measurements of biomarker levels at regular intervals as patients move from disease quiescence to disease flare. These approaches have begun to empower biomarkers as diagnostic and prognostic tools in LN and have revealed novel and sometimes unexpected roles for these biomarkers in the pathogenesis and prediction of LN disease activity.
引用
收藏
页码：71 / 79
页数：9
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