Asymmetric Direct 1,2-Addition of Aryl Grignard Reagents to Aryl Alkyl Ketones

被引：18

作者：

Osakama, Kazuki ^{[1
]}

Nakajima, Makoto ^{[1
]}

机构：

[1] Kumamoto Univ, Grad Sch Pharmaceut Sci, Chuo Ku, 5-1 Oe Honmachi, Kumamoto 8620973, Japan

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 02期

关键词：

CATALYTIC ENANTIOSELECTIVE ADDITION; ACID-BASE CATALYSTS; TITANIUM(IV) CATALYST; ORGANOZINC REAGENTS; MAGNESIUM COMPLEXES; SECONDARY ALCOHOLS; ARYLBORONIC ACIDS; TERTIARY ALCOHOLS; CHIRAL LIGANDS; ALDEHYDES;

D O I：

10.1021/acs.orglett.5b03379

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantioselective addition of Grignard reagents to ketones was promoted by a BINOL derivative bearing alkyl chains at the 3,3 '-positions. This is the first asymmetric direct aryl Grignard addition to ketones reported to date. A variety of tertiary diaryl alcohols could be obtained in high yields and enantioselectivities without using any other metal source.

引用

页码：236 / 239

页数：4

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