Transition-metal free direct difluoromethylthiolation of electron-rich aromatics with difluoromethanesulfonyl chloride

被引：43
|
作者：
Zhao, Xia [1 ]
Wei, Aoqi [1 ]
Li, Tianjiao [1 ]
Su, Zhiyang [1 ]
Chen, Jun [2 ]
Lu, Kui [3 ]
机构：
[1] Tianjin Normal Univ, Tianjin Key Lab Struct & Performance Funct Mol, Key Lab Inorgan Organ Hybrid Funct Mat Chem, Coll Chem,Minist Educ, Tianjin 300387, Peoples R China
[2] Beijing Inst Microchem, Beijing 100091, Peoples R China
[3] Tianjin Univ Sci & Technol, Coll Biotechnol, Tianjin 300457, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2017年 / 4卷 / 02期
基金：
中国国家自然科学基金;
关键词：
ALPHA-FLUORINATED ETHERS; ARYL SULFONYL HYDRAZIDES; SULFENYLATION REAGENTS; DIFLUOROMETHYLATING REAGENT; THIOETHERS; DIFLUOROCARBENE; THIOLATION; AMINES; ACID; PYRAZOLONES;
D O I：
10.1039/c6qo00581k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new method for phosphine-mediated difluoromethylthiolation of indole derivatives and other electronrich aromatics including pyrroles, pyrazolones, indolizine, and 1,3,5-trimethoxybenzene was developed using difluoromethanesulfonyl chloride. The additive n-Bu4NI was demonstrated to facilitate this reaction by generating iodine in situ, which could promote this transformation. The use of a transition-metal- free protocol, readily available reagents, and mild reaction conditions makes this protocol more practical than traditional methods.
引用
收藏
页码：232 / 235
页数：4
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