Using Small Molecules to Great Effect in Stem Cell Differentiation

被引:25
|
作者
Zaret, Kenneth S. [1 ]
机构
[1] Fox Chase Canc Ctr, Program Cell & Dev Biol, Philadelphia, PA 19111 USA
关键词
PLURIPOTENCY; MOUSE; MICE;
D O I
10.1016/j.stem.2009.04.012
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Several recent reports, including two Cell Stem Cell papers (Zhu et al., 2009 [this issue]; Borowiak et al., 2009), screened small molecule libraries for compounds that promote embryonic stem cell differentiation. Their combined success helps bypass challenges associated with using natural protein factors and has revealed insights into controlling stem cell differentiation.
引用
收藏
页码:373 / 374
页数:2
相关论文
共 50 条
  • [21] Discovering small molecules to control stem cell fate
    Andrews, Paul D.
    FUTURE MEDICINAL CHEMISTRY, 2011, 3 (12) : 1539 - 1549
  • [22] Small molecules for mesenchymal stem cell fate determination
    Cheng, Yu-Hao
    Dong, Jing-Cheng
    Bian, Qin
    WORLD JOURNAL OF STEM CELLS, 2019, 11 (12): : 1084 - 1103
  • [23] Synthetic small molecules that control stem cell fate
    Ding, S
    Wu, TYH
    Brinker, A
    Peters, EC
    Hur, W
    Gray, NS
    Schultz, PG
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (13) : 7632 - 7637
  • [24] Differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules
    Asumda, Faizal Z.
    Hatzistergos, Konstantinos E.
    Dykxhoorn, Derek M.
    Jakubski, Silvia
    Edwards, Jasmine
    Thomas, Emmanuel
    Schiff, Eugene R.
    DIFFERENTIATION, 2018, 101 : 16 - 24
  • [25] Directing Differentiation of Human Embryonic Stem Cells Toward Anterior Neural Ectoderm Using Small Molecules
    Surmacz, Beata
    Fox, Heather
    Gutteridge, Alex
    Lubitz, Sandra
    Whiting, Paul
    STEM CELLS, 2012, 30 (09) : 1875 - 1884
  • [26] Human stem cell-based screen for small molecules that promote oligodendrocyte differentiation, myelination, and neuronal survival
    Zack, D. J.
    Chamling, X.
    Sluch, V.
    Morales, I.
    Whartenby, K.
    Calabresi, P. A.
    MULTIPLE SCLEROSIS JOURNAL, 2017, 23 : 220 - 221
  • [27] Small acidic peptides and peptidomimetic molecules: Cell growth and differentiation
    Marsili, V
    Mancinelli, L
    Calzuola, I
    Gianfranceschi, GL
    RIVISTA DI BIOLOGIA-BIOLOGY FORUM, 2000, 93 (01): : 175 - 181
  • [28] A cell culture model for small intestinal stem cell function and differentiation
    不详
    JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2005, 40 (05): : 661 - 661
  • [29] Effect of dbcAMP on neural stem cell differentiation
    Chin, T. Y.
    Tsau, H. K.
    Lee, S. L.
    FEBS JOURNAL, 2008, 275 : 298 - 298
  • [30] The Effect of Physical Cues on the Stem Cell Differentiation
    Moghaddam, Mehrdad M.
    Bonakdar, Shahin
    Shariatpanahi, Mona R.
    Shokrgozar, Mohammad A.
    Faghihi, Shahab
    CURRENT STEM CELL RESEARCH & THERAPY, 2019, 14 (03) : 268 - 277