P2X receptors and trigeminal neuralgia

被引：8
|
作者：
Li, Jia-Juan [1 ]
Liu, Zeng-Xu [2 ]
Zhang, Ya-Ling [2 ]
Xue, Guo-Yong [2 ]
机构：
[1] Nanchang Univ, Clin Med Coll 2, Nanchang, Jiangxi, Peoples R China
[2] Nanchang Univ, Med Sch, Dept Anat, Nanchang, Jiangxi, Peoples R China
来源：
NEUROREPORT | 2019年 / 30卷 / 10期
基金：
中国国家自然科学基金;
关键词：
trigeminal ganglion; trigeminal neuralgia; NEUROVASCULAR COMPRESSION; NEUROPATHIC PAIN; UP-REGULATION; RAT MODEL; NERVE; EXPRESSION; GANGLION; TRPV1; ROOT; TETRAMETHYLPYRAZINE;
D O I：
10.1097/WNR.0000000000001266
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
There is currently no effective cure for trigeminal neuralgia (TN) - a relatively common disease that causes long-term pain in patients. Previous research has shown that ionotropic ATP signaling through excitatory and calcium-permeable P2X receptor channels plays a critical role in pathological pain generation and maintenance. In this paper, we review several hypotheses on the pathogenic mechanisms underlying TN. We further discuss pathways or agents that can target P2X expression in TN, thereby affecting pain induction and maintenance.
引用
收藏
页码：725 / 729
页数：5
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