Building units for N-backbone cyclic peptides .4. Synthesis of protected N-alpha-functionalized alkyl amino acids by reductive alkylation of natural amino acids

被引：31

作者：

Bitan, G ^{[1
]}

Muller, D ^{[1
]}

Kasher, R ^{[1
]}

Gluhov, EV ^{[1
]}

Gilon, C ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM,DEPT ORGAN CHEM,IL-91904 JERUSALEM,ISRAEL

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1997年 / 10期

关键词：

D O I：

10.1039/a608389g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the synthesis of protected N-alpha-(omega-Y-alkyl) amino acids (Y is a thio, amino or carboxy group) and related compounds by reductive alkylation of natural amino dids is reported, These new amino acids serve as building units for the synthesis of backbone-cyclic peptides, They are orthogonally protected at the alpha-amino position by butoxycarbonyl (Boc) or 9-fluorenylmethoxycarbonyl (Fmoc), using trimethylsilyl temporary protection, to allow for their incorporation into peptides by solid phase peptide synthesis.

引用

页码：1501 / 1510

页数：10

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