Synthesis of [1,2-C-13]- and [2,3-C-13]-labelled delta-aminolevulinic acid

被引：0
|
作者：
Bunce, RA
Schilling, CL
Rivera, M
机构：
[1] Department of Chemistry, Oklahoma State University, Stillwater
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1997年 / 39卷 / 08期
关键词：
doubly C-13-labeled delta-aminolevulinic acid (delta-ALA); C-13-labeled hemes; C-13; NMR; heme active site;
D O I：
10.1002/(SICI)1099-1344(199708)39:8<669::AID-JLCR17>3.0.CO;2-B
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
[1,2-C-13]- and [2,3-C-13]-labeled delta-aminolevulinic acids (delta-ALAs) have been prepared by a four-step sequence. [1,2-C-13]-ethyl bromoacetate was used to introduce the labels in the 1,2-labeled delta-ALA while [2-C-13]-ethyl bromoacetate and [5-C-13]-Meldrum's acid were used to introduce the labels in the 2,3-labeled derivative. These amino acid building blocks can, be used to prepare heme-containing proteins with labeled hemes according to a previously reported biosynthetic method.
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页码：669 / 675
页数：7
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