Synthesis of [1,2-C-13]- and [2,3-C-13]-labelled delta-aminolevulinic acid

被引：0

作者：

Bunce, RA

Schilling, CL

Rivera, M

机构：

[1] Department of Chemistry, Oklahoma State University, Stillwater

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1997年 / 39卷 / 08期

关键词：

doubly C-13-labeled delta-aminolevulinic acid (delta-ALA); C-13-labeled hemes; C-13; NMR; heme active site;

D O I：

10.1002/(SICI)1099-1344(199708)39:8<669::AID-JLCR17>3.0.CO;2-B

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

[1,2-C-13]- and [2,3-C-13]-labeled delta-aminolevulinic acids (delta-ALAs) have been prepared by a four-step sequence. [1,2-C-13]-ethyl bromoacetate was used to introduce the labels in the 1,2-labeled delta-ALA while [2-C-13]-ethyl bromoacetate and [5-C-13]-Meldrum's acid were used to introduce the labels in the 2,3-labeled derivative. These amino acid building blocks can, be used to prepare heme-containing proteins with labeled hemes according to a previously reported biosynthetic method.

引用

页码：669 / 675

页数：7

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