Copper-catalyzed asymmetric Michael reactions with a-amino acid amides: Synthesis of an optically active piperidine derivative

被引：0

作者：

Christoffers, J ^{[1
]}

Scharl, H ^{[1
]}

机构：

[1] Univ Stuttgart, Inst Organ Chem, D-70569 Stuttgart, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 2002卷 / 09期

关键词：

asymmetric synthesis; catalysis; C-C coupling; copper; Michael additions;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Quaternary stereocenters are obtained at room temperature in copper-catalyzed asymmetric Michael reactions with alpha-amino acid amides as chiral auxiliaries. L-Valine diethylamide was applied as a chiral auxiliary, and an optically active piperidine derivative was prepared with 97% ee. The optical purity of the product was established by GLC after cyclization to a hexahydroisoquinolonecarboxylate. ((C) Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002).

引用

页码：1505 / 1508

页数：4

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