Synthesis and characterization of acrylic monomer and its polymer with pendant acetaminophen and investigation of polymer ability for drug release

Nowadays, the increasing consumption of drugs have strongly propounded problems such as drug accessability, on-time usage with exact dose, daily multiusage, and the side effects being the most serious of all. The scientific community has always been searching ways for reduction of these difficulties. Drug controlled release system is one of the ways which has attracted considerable attention in recent years, and it is defined as the release of drug in specified parts of the body with a required dose and desirable specific rate which itself consists of various techniques, In this research the method employed is the chemically controlled release with 4- hydroxyphenyl acetamide (acetaminophen) as the drug. Thus, acetaminophen and acryloyl chloride are converted to an acrylic monomer, then the obtained monomer is polymerized, and finally the drug release ability of the polymers is tested in buffer solution. These tests show that the polymers are able to release drug but with insignificant amount and this as a preliminary step is a good sign and satisfactory.