LINC00673 silencing inhibits cell migration and invasion by suppressing PI3K/AKT signaling in glioma

被引：18
|
作者：
Zhang, Feng [1 ]
Huang, Yuen [2 ]
Wang, Bata [3 ]
Zhong, Cheng [4 ]
Liu, Xiaofeng [1 ]
Ding, Shanshan [5 ]
机构：
[1] Jinan Univ, Affiliated Hosp 1, Intens Care Unit, Guangzhou, Guangdong, Peoples R China
[2] Jinan Univ, Affiliated Hosp 1, Dongpu Branch, Dept Rehabil, Guangzhou, Guangdong, Peoples R China
[3] Jinan Univ, Affiliated Hosp 1, Dept Orthoped, Guangzhou, Guangdong, Peoples R China
[4] Jinan Univ, Affiliated Jiangmen Tradit Chinese Med Hosp, Dept Traumatol & Plast Surg, Jiangmen, Peoples R China
[5] Jinan Univ, Coll Chinese Language & Culture, 377 Shougouling Rd, Guangzhou 510610, Guangdong, Peoples R China
来源：
NEUROREPORT | 2018年 / 29卷 / 09期
关键词：
AKT; glioma; invasion; LINC00673; migration; phosphoinositide; 3-kinase; GLIOBLASTOMA CELLS; METASTASIS; EXPRESSION; PATHWAY;
D O I：
10.1097/WNR.0000000000001022
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
LINC00673 is an oncogene that plays a key role in various cancer types. However, the role of LINC00673 in glioma remains unclear. In this study, we examined its expression in glioma cells by quantitative real-time PCR and found higher expression of LINC00673 in glioma cells compared with that in normal human astrocytes. Furthermore, LINC00673 silencing inhibited the migration and invasion of U87MG and U118MG cells, phosphoinositide 3-kinase (PI3K) expression, and AKT phosphorylation. Moreover, activation of the PI3K/AKT signaling pathway by insulin-like Growth factor-1 abolished the inhibitory effect of LINC00673 silencing on the migration and invasion of U87MG and U118MG cells. In conclusion, LINC00673 silencing inhibits glioma cell migration and invasion by suppressing the PI3K/AKT signaling pathway, and it is a potential therapeutic target for the treatment of metastatic glioma.
引用
收藏
页码：718 / 722
页数：5
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