Long noncoding RNAs in intestinal epithelium homeostasis

被引:26
|
作者
Xiao, Lan [1 ,2 ]
Gorospe, Myriam [3 ]
Wang, Jian-Ying [1 ,2 ,4 ]
机构
[1] Univ Maryland, Sch Med, Dept Surg, Cell Biol Grp, Baltimore, MD 21201 USA
[2] Baltimore Vet Affairs Med Ctr, Baltimore, MD USA
[3] NIA, Lab Genet & Genotn, Intramural Res Program, NIH, Baltimore, MD 21224 USA
[4] Univ Maryland, Sch Med, Dept Pathol, Baltimore, MD 21201 USA
来源
关键词
gut permeability; intestinal mucosal renewal; microRNA; posttranscriptional regulation; RNA-binding proteins; BARRIER FUNCTION; BINDING; TRANSLATION; GROWTH; HUR; MICRORNAS; MECHANISMS; EXPRESSION; RENEWAL; NETWORK;
D O I
10.1152/ajpcell.00092.2019
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The epithelium of the mammalian intestinal mucosa is a rapidly self-renewing tissue in the body, and its homeostasis is preserved through well-controlled mechanisms. Long noncoding RNAs (lncRNAs) regulate a variety of biological functions and are intimately involved in the pathogenesis of diverse human diseases. Here we highlight the roles of several I neR NAs expressed in the intestinal epithelium, including uc.173, SPRY4-ITI , H19. and Gata6, in maintaining the integrity of the intestinal epithelium, focusing on the emerging evidence of lncRNAs in the regulation of intestinal mucosal regeneration and epithelial barrier function. We also discuss recent results that the interactions between lncRNAs with microRNAs and the RNA-binding protein HuR influence epithelial homeostasis. With rapidly advancing knowledge of lncRNAs, there is also growing recognition that lncRNAs in the intestinal epithelium might be promising therapeutic targets in our efforts to protect the integrity of the intestinal epithelium in response to stressful environments.
引用
收藏
页码:C93 / C100
页数:8
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