Synthesis of novel chemical probes for the study of tanshinone binding proteins

被引：8
|
作者：
Lee, Jin-Soo
Han, Sun-Young
Kim, Myong Sang
Yu, Chan-Mo
Kim, Myung Hee
Kim, Seong Hwan
Min, Yong Ki [1 ]
Kim, Bum Tae
机构：
[1] Korea Res Inst Chem Technol, Bioorgan Sci Div, Lab Chem Genom, Taejon 305600, South Korea
[2] Sungkyunkwan Univ, Dept Chem, Suwon 440746, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 18期
关键词：
tanshinone derivatives; osteoclastogenesis; tanshinone-protein(s); interactions; probes;
D O I：
10.1016/j.bmcl.2006.07.019
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Novel diazirine or biotin-labeled tanshinone probes were synthesized and evaluated for TRAP inhibitory activity against RANKL-induced osteoclastogenesis in RAW264.7 cells. We found that diazirine-labeled derivatives (18 and 20) are potent inhibitors of RANKL-induced osteoclastogenesis. IC50 values were 18.02 and 15.00 mu M, respectively. These probes will be useful reagents for investigating tanshinone-proteins interactions. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4733 / 4737
页数：5
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