Synthesis of novel chemical probes for the study of tanshinone binding proteins

被引：8

作者：

Lee, Jin-Soo

Han, Sun-Young

Kim, Myong Sang

Yu, Chan-Mo

Kim, Myung Hee

Kim, Seong Hwan

Min, Yong Ki ^{[1
]}

Kim, Bum Tae

机构：

[1] Korea Res Inst Chem Technol, Bioorgan Sci Div, Lab Chem Genom, Taejon 305600, South Korea

[2] Sungkyunkwan Univ, Dept Chem, Suwon 440746, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 18期

关键词：

tanshinone derivatives; osteoclastogenesis; tanshinone-protein(s); interactions; probes;

D O I：

10.1016/j.bmcl.2006.07.019

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel diazirine or biotin-labeled tanshinone probes were synthesized and evaluated for TRAP inhibitory activity against RANKL-induced osteoclastogenesis in RAW264.7 cells. We found that diazirine-labeled derivatives (18 and 20) are potent inhibitors of RANKL-induced osteoclastogenesis. IC50 values were 18.02 and 15.00 mu M, respectively. These probes will be useful reagents for investigating tanshinone-proteins interactions. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4733 / 4737

页数：5

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