We prove that guarding the vertices of a rectilinear polygon P, whether by guards lying at vertices of P, or by guards lying on the boundary of P, or by guards lying anywhere in P, is NP-hard. For the first two proofs (i.e., vertex guards and boundary guards), we construct a reduction from minimum piercing of 2-intervals. The third proof is somewhat simpler; it is obtained by adapting a known reduction from minimum line cover. We also consider the problem of guarding the vertices of a 1.5D rectilinear terrain by vertex guards. We establish an interesting connection between this problem and the problem of computing a minimum clique cover in chordal graphs. This connection yields a 2-approximation algorithm for the guarding problem.
