Effect of Sulfation and Molecular Weight on Anticoagulant Activity of Dextran

被引：13
|
作者：
Drozd, N. N. [1 ]
Logvinova, Yu. S. [1 ]
Torlopov, M. A. [2 ]
Udoratina, E. V. [2 ]
机构：
[1] Minist Hlth Russian Federat, Natl Res Ctr Hematol, Moscow, Russia
[2] Russian Acad Sci, Inst Chem, Komi Sci Ctr, Ural Div, Syktyvkar, Komi Republic, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2017年 / 162卷 / 04期
关键词：
dextran; dextran sulfate; anticoagulant activity; AGGREGATION;
D O I：
10.1007/s10517-017-3640-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Sulfation (to 2.8) of dextrans with molecular weight of 150 and 20 kDa was followed by the appearance of anticoagulant activity that increased with decreasing their molecular weight and did not depend on antithrombin, plasma inhibitor of serine proteases of the blood coagulation system. Antithrombin activity of dextran sulfate with a molecular weight of 20 kDa reached 12.6-15.3 U/mg. Dextran sulfates with molecular weights of 20 and 150 kDa did not potentiate ADP-induced human platelet aggregation.
引用
收藏
页码：462 / 465
页数：4
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