Hypotriglyceridemic and hepatoprotective effect of pumpkin (Cucurbita moschata) seed flour in an experimental model of dyslipidemia

被引：6

作者：

de Farias, Luciana Melo ^{[1
,2
]}

Brito, Ana Karolinne da Silva ^{[2
]}

Oliveira, Amanda Suellenn da Silva Santos ^{[1
,2
]}

Lima, Geovanni de Morais ^{[2
]}

Rodrigues, Lays Arnaud Rosal Lopes ^{[1
]}

de Carvalho, Vanessa Brito Lira ^{[1
]}

Cunha, Francisco Valmor Macedo ^{[3
]}

Pereira, Cristian Francisco de Carvalho ^{[4
]}

Rizzo, Marcia dos Santos ^{[4
]}

Nunes, Paulo Humberto Moreira ^{[2
]}

Frota, Karoline de Macedo Goncalves ^{[1
]}

de Lima, Alessandro ^{[5
]}

dos Santos, Alessandro Carvalho Alves ^{[6
]}

Alberto, Norma Sueli Marques da Costa ^{[5
]}

Arcanjo, Daniel Dias Rufino ^{[2
]}

Martins, Maria do Carmo de Carvalho e ^{[2
,7
]}

机构：

[1] Univ Fed Piaui, Dept Nutr, Teresina, PI, Brazil

[2] Univ Fed Piaui, Dept Biophys & Physiol, Teresina, PI, Brazil

[3] Fed Univ Delta Parnaiba, Dept Physiotherapy, Parnaiba, PI, Brazil

[4] Univ Fed Piaui, Dept Morphol, Teresina, PI, Brazil

[5] Fed Inst Piaui, Teresina, PI, Brazil

[6] Uninovafapi Univ Ctr, Teresina, PI, Brazil

[7] Campus Univ Minist Petronio Portela, Dept Biophys & Physiol, S-N Ininga, BR-64049550 Teresina, PI, Brazil

来源：

SOUTH AFRICAN JOURNAL OF BOTANY | 2022年 / 151卷

关键词：

Cucurbita moschata; pumpkin; seeds; dyslipidemia; steatosis; DENSITY-LIPOPROTEIN CHOLESTEROL; FATTY LIVER-DISEASE; CARDIOVASCULAR-DISEASE; BIOACTIVE COMPOUNDS; LIPID FRACTIONS; FRUIT EXTRACT; DIET; RISK; FOOD; COMPONENTS;

D O I：

10.1016/j.sajb.2022.05.008

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

This study evaluated the effect of pumpkin (Cucurbita moschata) seed flour on the lipid profile and bio-markers of liver function in an experimental dyslipidemia. The hamsters were divided into three groups: nor-mal control group (n = 8) fed commercial feed; dyslipidemia control group (n = 8) with dyslipidemia induced by consumption of feed enriched with saturated fat and cholesterol (dyslipidemic diet with 13.5% coconut fat and 0.1% cholesterol); pumpkin seed group (n = 10), maintained on a dyslipidemic diet plus pumpkin seed flour. After 28 days of treatment, the treatment with a diet enriched with pumpkin seeds significantly reduced the serum triglycerides, increased the faecal excretion of cholesterol, and reduced the accumulation of lipids in the hepatocytes, thus decreasing the degree of hepatic steatosis. In the experimental model used in this study, pumpkin seed flour had a hypotriglyceridemic property and a hepatoprotective effect in rela-tion to hepatic steatosis. (c) 2022 SAAB. Published by Elsevier B.V. All rights reserved.

引用

页码：484 / 492

页数：9

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