The effects of phase feeding Lys during gestation on sow reproductive performance and piglet vigor were evaluated. Females (n=45) were blocked by parity and randomly allotted to one of 3 feeding regimens: 12 g SID Lys/d (Control), 12 g SID Lys/d d2 - 89 and 17 g SID Lys/d d90 - 110 d of gestation (PF 1) and 10, 8.5, and 7 g SID Lys/d d2 - 89 for gilts, parity 1 and parity 2+, respectively and 17 g SID Lys/d d90 - 110 d of gestation (PF 2). Dietary energy and essential AA:Lys met NRC recommendations. Sow reproductive performance was defined as litter characteristics at birth and piglet vigor as cord cortisol and immunocrit at d2 of age from 6 and 4 piglets/litter, respectively. Data were analyzed as a randomized complete block with sow(block) as the random variable and means separation using Tukey's adjustment. Maternal Lys intake had no impact on total born, liveborn (Con:13.9 +/- 0.7, PF1:12.8 +/- 0.8, PF2:12.5 +/- 0.7), stillborn, or mummies. Piglet birth weight was lower (P=0.01) in PF2 litters (1.26 +/- 0.03 kg) than Con (1.32 +/- 0.03 kg) and PF1 (1.38 +/- 0.03 kg). Gestation Lys intake did not affect serum immunocrit levels in piglets. Heavy piglets (>1.4 kg at birth; 0.184 +/- 0.01) had 12% greater immunocrit value than light piglets (<= 1.0 kg at birth; 0.163 +/- 0.01). Cord cortisol levels did not differ by maternal treatment. In a single gestation, phase feeding Lys intake had minimal impact on litter characteristics or vigor at birth.