Systemic lupus erythematosus, complicated with refractory skin ulcers, treated successfully with bosentan

被引：6

作者：

Suzuki, Eiji ^{[1
]}

Kyozuka, Hyo ^{[1
]}

Nishida, Toru ^{[2
]}

Kanno, Takashi ^{[1
]}

Ohira, Hiromasa ^{[3
]}

机构：

[1] Ohta Nishinouchi Hosp, Div Rheumatol, Fukushima 9638022, Japan

[2] Ohta Nishinouchi Hosp, Div Dermatol, Fukushima 9638022, Japan

[3] Fukushima Med Univ, Sch Med, Dept Internal Med 2, Fukushima 9601295, Japan

来源：

MODERN RHEUMATOLOGY | 2009年 / 19卷 / 04期

关键词：

Bosentan; Endothelin; Pulmonary hypertension (PH); Skin ulcer; Systemic lupus erythematosus (SLE); PULMONARY ARTERIAL-HYPERTENSION; REVISED CRITERIA; DIGITAL ULCERS; ENDOTHELIN-1; CLASSIFICATION; EXPRESSION; SCLEROSIS; THERAPY;

D O I：

10.1007/s10165-009-0184-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 20-year-old woman was admitted to our hospital because of bilateral pretibial edema. Administration of prednisolone was started after she was diagnosed with systemic lupus erythematosus (SLE). However, skin ulcers on her extremities developed; they subsequently worsened with tapering of prednisolone. She also developed pulmonary hypertension (PH). Her skin ulcers improved considerably after administration of bosentan, an endothelin receptor antagonist. Bosentan may be efficacious not only for PH but also for refractory skin ulcers.

引用

页码：447 / 451

页数：5

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