Copper Complexes as Bioinspired Models for Lytic Polysaccharide Monooxygenases

被引：36

作者：

Concia, Alda Lisa ^{[1
]}

Beccia, Maria Rosa ^{[2
]}

Orio, Maylis ^{[1
]}

Ferre, Francine Terra ^{[3
]}

Scarpellini, Marciela ^{[3
]}

Biaso, Frederic ^{[2
]}

Guigliarelli, Bruno ^{[2
]}

Reglier, Marius ^{[1
]}

Simaan, A. Jalila ^{[1
]}

机构：

[1] Aix Marseille Univ, CNRS, iSm2, Cent Marseille, Marseille, France

[2] Aix Marseille Univ, CNRS, BIP, Marseille, France

[3] Univ Fed Rio de Janeiro, Inst Quim, Ilha Cidade Univ, BR-21941490 Rio De Janeiro, Brazil

来源：

INORGANIC CHEMISTRY | 2017年 / 56卷 / 03期

关键词：

CHEMISTRY; OXIDATION; DEGRADATION; MECHANISMS; CONVERSION; DINUCLEAR; CELLULOSE; RELEVANT; CLEAVAGE;

D O I：

10.1021/acs.inorgchem.6b02165

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We report here two copper complexes as first functional models for lytic polysaccharide monooxygenases, mononuclear copper-containing enzymes involved in recalcitrant polysaccharide breakdown. These complexes feature structural and spectroscopic properties similar to those of the enzyme. In addition, they catalyze oxidative cleavage of the model substrate p-nitrophenyl-beta-D-glucopyranoside. More importantly, a particularly stable copper(II) hydroperoxide intermediate is detected in the reaction conditions.

引用

页码：1023 / 1026

页数：4

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