Modifying histories and initiating meiotic recombination: New answers to an old question

被引：10
|
作者：
Maleki, S [1 ]
Keeney, S [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Program Mol Biol, New York, NY 10021 USA
来源：
CELL | 2004年 / 118卷 / 04期
关键词：
D O I：
10.1016/j.cell.2004.08.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
It is well documented that the formation of the DNA double-strand breaks (DSBs) that initiate meiotic recombination is influenced by chromatin and larger scale chromosome organization, but the molecular nature of this influence has remained elusive. Several recent studies, including Reddy and Villeneuve (2004, this issue of Cell), shed light on this issue by revealing roles for posttranslational histone modifications in promoting DSB formation.
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页码：404 / 406
页数：3
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