Application of DNA-Alkylating Pyrrole-Imidazole Polyamides for Cancer Treatment

被引：8
|
作者：
Maeda, Rina [1 ]
Bando, Toshikazu [2 ]
Sugiyama, Hiroshi [2 ,3 ]
机构：
[1] Kyoto Univ, Grad Sch Adv Integrated Studies Human Survivabil, Sakyo Ku, Kyoto 6068306, Japan
[2] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakura Ku, Kyoto 6068502, Japan
[3] Kyoto Univ, Inst Integrated Cell Mat Sci iCeMS, Sakyo Ku, Kyoto 6068501, Japan
来源：
CHEMBIOCHEM | 2021年 / 22卷 / 09期
关键词：
cancer; DNA alkylation; DNA recognition; drug discovery; sequence-specificity;
D O I：
10.1002/cbic.202000752
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pyrrole-imidazole (PI) polyamides, which target specific DNA sequences, have been studied as a class of DNA minor-groove-binding molecules. To investigate the potential of compounds for cancer treatment, PI polyamides were conjugated with DNA-alkylating agents, such as seco-CBI and chlorambucil. DNA-alkylating PI polyamides have attracted attention because of their sequence-specific alkylating activities, which contribute to reducing the severe side effects of current DNA-damaging drugs. Many of these types of conjugates have been developed as new candidates for anticancer drugs. Herein, we review recent progress into research on DNA-alkylating PI polyamides and their sequence-specific action on targets associated with cancer development.
引用
收藏
页码：1538 / 1545
页数：8
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