Inhibition of PI3K and MEK: It Is All about Combinations and Biomarkers

被引：33
|
作者：
Rexer, Brent N.
Ghosh, Ritwik
Arteaga, Carlos L. [1 ]
机构：
[1] Vanderbilt Univ, Sch Med, Div Oncol, Dept Med, Nashville, TN 37232 USA
来源：
CLINICAL CANCER RESEARCH | 2009年 / 15卷 / 14期
关键词：
CANCER; MTOR; ACTIVATION;
D O I：
10.1158/1078-0432.CCR-09-0872
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A small molecule inhibitor of MAP/ERK kinase (MEK) was effective against human breast cancer cells with a basal-like gene expression signature. Antitumor activity was limited by both feedback upregulation of phosphatidylinositol-3 kinase (PI3K)/AKT upon inhibition of MEK as well as loss of the phosphatase PTEN. Therefore, MEK inhibitors should preferably be investigated in combination with PI3K inhibitors in basal-like breast cancers. (Clin Cancer Res 2009;15(14) July 2009).
引用
收藏
页码：4518 / 4520
页数：3
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