POSITRON EMISSION TOMOGRAPHY IN SURVEILLANCE OF HEAD AND NECK SQUAMOUS CELL CARCINOMA AFTER DEFINITIVE CHEMORADIOTHERAPY

被引：29
|
作者：
Wang, Yi-Fen [1 ,2 ]
Liu, Ren-Shyan [3 ]
Chu, Pen-Yuan [1 ]
Chang, Feng-Chi [4 ]
Tai, Shyh-Kuan [1 ,2 ]
Tsai, Tung-Lung [1 ,2 ]
Huang, Jui-Lin [1 ]
Chang, Shyue-Yih [1 ]
机构：
[1] Taipei Vet Gen Hosp, Dept Otorhinolaryngol Head & Neck Surg, Taipei, Taiwan
[2] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan
[3] Taipei Vet Gen Hosp, Dept Nucl Med, Taipei, Taiwan
[4] Taipei Vet Gen Hosp, Dept Radiol, Taipei, Taiwan
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2009年 / 31卷 / 04期
关键词：
head and neck squamous cell carcinoma; positron emission tomography; chemoradiotherapy; computed tomography; metastasis; FDG-PET; RADIATION TREATMENT; CONCURRENT CHEMOTHERAPY; TREATMENT RESPONSE; CANCER; RADIOTHERAPY; THERAPY; F-18-FLUORODEOXYGLUCOSE; DISSECTION; RECURRENCE;
D O I：
10.1002/hed.20978
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background. We assessed the role of F-18-fluorodeoxy-glucose positron emission tomography (PET) in detecting head and neck squamous cell carcinoma (HNSCC) after definitive chemoradiotherapy (CRT). Methods, A prospective study presented 80 PET before and after CRT for 44 patients, including 44 first-time post-CRT scans performed between 12 and 17 weeks after radiotherapy completion, as well as 10 repeated scans in the subsequent follow-up. PET interpretations were compared with clinicopathologic outcomes. Results. PET demonstrated better performance than CT in post-CRT surveillance. Considering all 54 post-CRT PET scans, sensitivity for detecting primary tumors was 100%, specificity 93%, positive predictive value (PPV) 80%, and negative predictive value (NPV) 100%. For cervical diseases, sensitivity was 100%, specificity 98%, PPV 92%, and NPV 100%. For distant metastases, sensitivity was 100%, specificity 98%, PPV 86%, and Ni 100%. Conclusions. Negative PET readings were reliable for predicting free of HINSCC and helpful for selected patients in post-CRT surveillance. (C) 2009 Wiley Periodicals, Inc. Head Neck 31:442-451, 2009
引用
收藏
页码：442 / 451
页数：10
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