Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women

被引：50

作者：

Chen, Kexin ^{[1
]}

Ma, Hongxia ^{[2
]}

Li, Lian ^{[1
]}

Zang, Rongyu ^{[3
]}

Wang, Cheng ^{[2
]}

Song, Fengju ^{[1
]}

Shi, Tingyan ^{[3
,4
]}

Yu, Dianke ^{[5
]}

Yang, Ming ^{[6
]}

Xue, Wenqiong ^{[7
]}

Dai, Juncheng ^{[2
]}

Li, Shuang ^{[8
]}

Zheng, Hong ^{[1
]}

Wu, Chen ^{[5
]}

Zhang, Ying ^{[7
]}

Wu, Xiaohua ^{[3
]}

Li, Dake ^{[9
]}

Xue, Fengxia ^{[10
]}

Li, Haixin ^{[1
]}

Jiang, Zhi ^{[11
]}

Liu, Jibin ^{[12
]}

Liu, Yuexin ^{[13
]}

Li, Pei ^{[1
]}

Tan, Wen ^{[5
]}

Han, Jing ^{[2
]}

Jie, Jiang ^{[2
]}

Hao, Quan ^{[14
]}

Hu, Zhibin ^{[2
]}

Lin, Dongxin ^{[5
]}

Ma, Ding ^{[8
]}

Jia, Weihua ^{[7
]}

Shen, Hongbing ^{[2
]}

Wei, Qingyi ^{[4
,15
]}

机构：

[1] Tianjin Med Univ, Canc Inst & Hosp, Key Lab Canc Prevent & Therapy Tianjin, Natl Clin Res Ctr Canc,Dept Epidemiol & Biostat, Tianjin 300060, Peoples R China

[2] Nanjing Med Univ, Sch Publ Hlth, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, State Key Lab Reprod Med, Nanjing 211166, Jiangsu, Peoples R China

[3] Fudan Univ, Shanghai Canc Ctr, Dept Gynecol Oncol, Shanghai 200032, Peoples R China

[4] Fudan Univ, Shanghai Canc Ctr, Inst Canc, Shanghai 200032, Peoples R China

[5] Chinese Acad Med Sci, Canc Inst & Hosp, Dept Etiol & Carcinogenesis, Beijing 100021, Peoples R China

[6] Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing 100029, Peoples R China

[7] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol Southern China, Guangzhou 510060, Guangdong, Peoples R China

[8] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Obstet & Gynecol, Wuhan 430030, Hubei, Peoples R China

[9] Nanjing Univ TCM, Affiliated Hosp, Jiangsu Prov Hosp TCM, Dept Gynecol, Nanjing 210029, Jiangsu, Peoples R China

[10] Tianjin Med Univ, Gen Hosp, Dept Gynecol & Obstet, Tianjin 300052, Peoples R China

[11] Nanjing Med Univ, Jiangsu Canc Hosp, Dept Gynecol Surg, Nanjing 210009, Jiangsu, Peoples R China

[12] Nantong Tumor Hosp, Dept Tissue Bank, Nantong 226361, Jiangsu, Peoples R China

[13] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

[14] Tianjin Med Univ, Canc Inst & Hosp, Dept Urol, Tianjin 300060, Peoples R China

[15] Duke Univ, Med Ctr, Duke Canc Inst, Durham, NC 27710 USA

来源：

NATURE COMMUNICATIONS | 2014年 / 5卷

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

DIFFERENTIATION ANTIGEN NY-BR-1; GTPASE-ACTIVATING PROTEINS; ABO BLOOD-GROUP; BETA TYPE-I; RISK; POLYMORPHISM; BREAST; GENES; METAANALYSIS; EXPRESSION;

D O I：

10.1038/ncomms5682

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ovarian cancer is the leading cause of death from gynaecological malignancies worldwide. Here we perform a three-stage genome-wide association study (GWAS) in Han Chinese women to identify risk genetic variants for epithelial ovarian cancer (EOC). We scan 900,015 single-nucleotide polymorphisms (SNPs) in 1,057 EOC cases and 1,191 controls in stage I, and replicate 41 SNPs (P-meta<10(-4)) in 960 EOC cases and 1,799 controls (stage II), and an additional 492 EOC cases and 1,004 controls (stage III). Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P-meta = 1.88 x 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P-meta = 2.62 x 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P-meta = 1.14 x 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P-meta = 8.57 x 10(-7)) (P<0.05 in all three stages). These results may advance our understanding of genetic susceptibility to EOC.

引用

页数：7

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