Regulation of Breast Cancer Metastasis by Atypical Chemokine Receptors

被引：2
|
作者：
Cheng, Xiaoyun [2 ]
Hung, Mien-Chie [1 ,2 ,3 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Unit 108, Houston, TX 77030 USA
[2] Univ Texas Houston, Grad Sch Biomed Sci, Canc Biol Program, Houston, TX USA
[3] China Med Univ & Hosp, Grad Inst Canc Biol, Ctr Mol Med, Taichung 404, Taiwan
来源：
CLINICAL CANCER RESEARCH | 2009年 / 15卷 / 09期
关键词：
D O I：
10.1158/1078-0432.CCR-09-0141
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The interaction between chemokines and their G-protein-coupled receptors plays an important role in promoting metastasis of different kinds of human cancers. However, the expression of an atypical chemokine receptor, CCX-CKR, which serves as a decoy receptor to attract chemokines, inhibits the growth and metastasis of breast cancer by sequestration of chemokines.
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页码：2951 / 2953
页数：3
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