B Lymphocytes Are Predictors of Insulin Resistance in Women with Gestational Diabetes Mellitus

被引：17
|
作者：
Zhuang, Yan [1 ]
Zhang, Jin [1 ]
Li, Yiwei [1 ]
Gu, Hongqin [1 ]
Zhao, Jinyan [1 ]
Sun, Ya [1 ]
Wang, Rencheng [1 ]
Zhang, Chunyan [1 ,2 ]
Chen, Wen [1 ,3 ]
Weng, Jianrong [1 ]
Qi, Lan [1 ]
Lu, Huifang [1 ]
Zhang, Jiarong [1 ]
Liu, Qin [4 ]
He, Yinyan [1 ]
Xu, Xianming [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Gen Hosp, Dept Obstet & Gynecol, 100 Haining Rd, Shanghai 200080, Peoples R China
[2] Shangyou Maternal & Child Care Serv Ctr, Dept Obstet & Gynecol, 9 Shuinan Ave, Ganzhou City 341200, Jiangxi, Peoples R China
[3] Fuluan Maternal & Child Care Serv Ctr, Dept Obstet & Gynecol, 2 Kaiyuan Rd, Jingdezhen City 333400, Jiangxi, Peoples R China
[4] Wistar Inst Anat & Biol, 3601 Spruce St, Philadelphia, PA 19104 USA
来源：
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS | 2019年 / 19卷 / 03期
关键词：
B lymphocytes; insulin resistance; inflammation; GDM; immune; IgA; flow cytometry; INFLAMMATION; CELLS; METABOLISM; OBESITY; RISK;
D O I：
10.2174/1871530319666190101130300
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Backgroud: The present study aimed to investigate the association between immune cells and gestational diabetes mellitus (GDM) and identify a reasonable predictor of insulin resistance in women with GDM. Objective: The clinical and biochemical characteristics of 124 women with GDM and 168 healthy pregnant women were compared. Methods: The percentage of immune cells in the blood of the subjects was analyzed by flow cytometry. Pearson's correlation analysis revealed the correlation between the percentage of B lymphocytes and insulin resistance. A cutoff point was determined for the percentage of B lymphocytes, based on insulin resistance, using receiver operating characteristic (ROC) curves. Results: Compared to the healthy pregnant women, the percentages of B lymphocytes and IgA produced by B-cells were significantly different in women with GDM. The percentage of B lymphocytes was positively related to insulin resistance.The number of 14.05% of B lymphocytes was an optimal cutoff point that predicted the insulin resistance in women with GDM. Conclusion: The percentage of B lymphocytes was positively associated with insulin resistance, and hence, might serve as an appropriate predictor of insulin resistance in women with GDM.
引用
收藏
页码：358 / 366
页数：9
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