Carbene Catalyzed Asymmetric Synthesis of Selenylated δ-Lactones via [4+2] Annulation of Selenyl Vinyl Ketones and Enals

被引：3
|
作者：
Verma, Ram Subhawan [1 ]
Talukdar, Ranadeep [1 ]
Azaz, Tazeen [1 ]
Tiwari, Bhoopendra [1 ]
机构：
[1] Ctr Biomed Res, Dept Biol & Synthet Chem, SGPGIMS Campus,Raebareli Rd, Lucknow 226014, Uttar Pradesh, India
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 23期
关键词：
Selenylated Dihydropyranones; Asymmetric Synthesis; NHC; Enones; Enals; N-HETEROCYCLIC CARBENE; DIELS-ALDER REACTIONS; ONE-POT SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; MICHAEL ADDITION; ALDEHYDES; CYCLIZATION; SELENOCYANATION; TRIFLUOROMETHYL;
D O I：
10.1002/adsc.202201036
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A direct (organo)catalytic method for the synthesis of chiral selenylated delta-lactones via [4+2] annulation of selenyl vinyl ketones with enals has been achieved. The C5-selenylated dihydropyranones were obtained in 54-88% yield with 90-99% enantioselectivity.
引用
收藏
页码：4031 / 4035
页数：5
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