A practical and efficient method for late-stage deuteration of terminal alkynes with silver salt as catalyst

被引：12
|
作者：
Wu, Ding-Chuan [1 ,2 ]
Bai, Jing-Wen [1 ,2 ]
Guo, Lei [1 ,2 ]
Hu, Guang-Qi [1 ,2 ]
Liu, Kai-Hui [1 ,2 ]
Sheng, Fei-Fei [1 ,2 ]
Zhang, Hong-Hai [1 ,2 ]
Sun, Zheng-Yi [1 ,2 ]
Shen, Kang [1 ,2 ]
Liu, Xiang [1 ,2 ]
机构：
[1] Nanjing Tech Univ Nanjing Tech, Jiangsu Natl Synergist Innovat Ctr Adv Mat SICAM, Key Lab Flexible Elect KLOFE, 30 Puzhu Rd, Nanjing 211816, Peoples R China
[2] Nanjing Tech Univ Nanjing Tech, Inst Adv Mat IAM, Jiangsu Natl Synergist Innovat Ctr Adv Mat SICAM, 30 Puzhu Rd, Nanjing 211816, Peoples R China
来源：
TETRAHEDRON LETTERS | 2021年 / 66卷
基金：
中国国家自然科学基金;
关键词：
Late-stage deuteration; Terminal alkyne; Silver salt; SELECTIVE DEUTERATION; H FUNCTIONALIZATION; BR/D EXCHANGE; DEUTERIUM; PALLADIUM; ALKYNYLATION; STRATEGY; TRITIUM; DRUG;
D O I：
10.1016/j.tetlet.2020.152807
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A practical and efficient H/D exchange method for selective deuteration of terminal alkynes was disclosed. The reaction was simply performed with CF3COOAg as catalyst at room temperature, affording products with high level of deuterium incorporation. The excellent site-selectivity and promising functional group tolerance of this protocol enabled deuteration of pharmaceuticals and nature product derivatives. (C) 2021 Elsevier Ltd. All rights reserved.
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页数：4
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