Sex Differences in Effectiveness of Extended-Release Stimulant Medication among Adolescents with Attention-Deficit/Hyperactivity Disorder

被引:20
|
作者
Mikami, Amori Yee [1 ]
Cox, Daniel J. [2 ]
Davis, Margaret T. [2 ]
Wilson, H. Kent [3 ]
Merkel, R. Lawrence [2 ]
Burket, Roger [2 ]
机构
[1] Univ Virginia, Dept Psychol, Charlottesville, VA 22904 USA
[2] Univ Virginia, Dept Psychiat Med, Behav Med Ctr, Charlottesville, VA 22908 USA
[3] Univ Virginia, Curry Sch Educ, Charlottesville, VA 22904 USA
关键词
ADHD; Adolescents; Girls; Stimulant medication; Extended-release; DEFICIT-HYPERACTIVITY DISORDER; CHILDREN; METHYLPHENIDATE; ADHD; GIRLS; PHARMACOKINETICS; PERFORMANCE; GENDER; PHARMACOTHERAPY; INHIBITION;
D O I
10.1007/s10880-009-9165-8
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
This study examined whether adolescent females with attention-deficit/hyperactivity disorder (ADHD) are differentially responsive than their male counterparts to extended-release stimulant medications. This investigation may bear special importance for an adolescent (as opposed to child) population, because hormonal and metabolism differences between sexes are most likely to emerge at this time. Male (n = 19) and female (n = 16) adolescents, ages 16-19 with ADHD, participated in a randomized, double-blind crossover study evaluating the effectiveness of osmotic-release methylphenidate, extended release amphetamine salts, placebo, and routine limited medication regimen. Medication efficacy was evaluated using ADHD symptom ratings from adolescent self-report and parent report, along with objective measures of inattention and hyperactivity/impulsivity during driving performance and neuropsychological tasks. Males and females were largely equivalent in impairment, and medication was similarly effective in reducing symptoms. No interactions were found between sex and medication on any measure of effectiveness or side effects. This finding suggests that the efficacy and tolerability of extended-release stimulant medications is equivalent for male and female adolescents with ADHD.
引用
收藏
页码:233 / 242
页数:10
相关论文
共 50 条
  • [21] A Controlled Trial of Extended-Release Guanfacine and Psychostimulants for Attention-Deficit/Hyperactivity Disorder
    Wilens, Timothy E.
    Bukstein, Oscar
    Brams, Matthew
    Cutler, Andrew J.
    Childress, Ann
    Rugino, Thomas
    Lyne, Andrew
    Grannis, Kara
    Youcha, Sharon
    JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2012, 51 (01): : 74 - 85
  • [22] Pharmacokinetic Profile of Clonidine Hydrochloride Extended-Release Tablets in Children and Adolescents with Attention-Deficit Hyperactivity Disorder
    Silva, Raul R.
    Markowitz, John S.
    Muniz, Rafael
    Wang, Chao
    Yoon, Mija
    Wargin, William
    Cavanaugh, Paul F.
    JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 2011, 21 (06) : 632 - 632
  • [23] Extended-Release Viloxazine for the Treatment of Attention-Deficit Hyperactivity Disorder in School-Age Children and Adolescents
    Raible, Haley
    D'Souza, Manoranjan S.
    ANNALS OF PHARMACOTHERAPY, 2023, 57 (12) : 1436 - 1448
  • [24] Guanfacine Extended-Release In Attention Deficit Hyperactivity Disorder
    Muir, Victoria J.
    Perry, Caroline M.
    DRUGS, 2010, 70 (13) : 1693 - 1702
  • [25] A COST-EFFECTIVENESS ANALYSIS OF GUANFACINE EXTENDED-RELEASE TREATMENT IN PEDIATRIC ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
    Maeda, S.
    Shimozuma, K.
    Takeda, Y.
    VALUE IN HEALTH, 2016, 19 (07) : A841 - A841
  • [26] Guanfacine extended release for children and adolescents with attention-deficit/hyperactivity disorder: efficacy following prior stimulant treatment
    Huss, M.
    Hervas, A.
    Dirks, B.
    Bliss, C.
    Prochazka, J.
    Cutler, A.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2016, 26 : S737 - S737
  • [27] COST-EFFECTIVENESS OF GUANFACINE EXTENDED-RELEASE VERSUS ATOMOXETINE FOR THE TREATMENT OF CHILDREN AND ADOLESCENTS WITH ATTENTION-DEFICIT/HYPERACTIVITY DISORDER IN CANADA
    Lachaine, J.
    Sikirica, V
    Mathurin, K.
    VALUE IN HEALTH, 2014, 17 (03) : A213 - A214
  • [28] Dexmethylphenidate extended release - In attention-deficit hyperactivity disorder
    Robinson, Dean M.
    Keating, Gillian M.
    DRUGS, 2006, 66 (05) : 661 - 668
  • [29] Guanfacine extended release for the treatment of attention-deficit/hyperactivity disorder in children and adolescents
    Connor, Daniel F.
    Arnsten, Amy F. T.
    Pearson, Geraldine S.
    Greco, Gabriella F.
    EXPERT OPINION ON PHARMACOTHERAPY, 2014, 15 (11) : 1601 - 1610
  • [30] Predictors of Stimulant Medication Continuity in Children with Attention-Deficit/Hyperactivity Disorder
    Kamimura-Nishimura, Kelly, I
    Brinkman, William B.
    Epstein, Jeffery N.
    Zhang, Yin
    Altaye, Mekibib
    Simon, John
    Modi, Avani C.
    Froehlich, Tanya E.
    JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS, 2022, 43 (06): : 311 - 319