Functional and structural evaluation in the lungs of children with repaired congenital diaphragmatic hernia

被引:5
|
作者
Koh, June-Young [1 ,2 ]
Jung, Euiseok [1 ]
Goo, Hyun Woo [3 ,4 ]
Kim, Seong-Chul [5 ]
Kim, Dae Yeon [5 ]
Namgoong, Jung-Man [5 ]
Lee, Byong Sop [1 ]
Kim, Ki-Soo [1 ]
Kim, Ellen Ai-Rhan [1 ]
机构
[1] Univ Ulsan, Dept Pediat, Asan Med Ctr, Coll Med, Seoul, South Korea
[2] Korea Adv Inst Sci & Technol KAIST, Grad Sch Med Sci & Engn, Daejeon, South Korea
[3] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Radiol, Seoul, South Korea
[4] Univ Ulsan, Coll Med, Asan Med Ctr, Res Inst Radiol, Seoul, South Korea
[5] Univ Ulsan, Dept Pediat Surg, Asan Med Ctr, Coll Med, Seoul, South Korea
关键词
Congenital diaphragmatic hernia; Pulmonary function tests; Computed tomography; Risk factors;
D O I
10.1186/s12887-021-02586-3
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Background: To evaluate the long-term functional and structural pulmonary development in children with repaired congenital diaphragmatic hernia (CDH) and to identify the associated perinatal-neonatal risk factors. Methods: Children with repaired CDH through corrective surgery who were born at gestational age >= 35 weeks were included in this analysis. Those who were followed for at least 5 years were subjected to spirometry and chest computed tomography for evaluation of their functional and structural growth. Main bronchus diameters and lung volumes (total, left/right) were measured. According to total lung volume (TLV) relative to body surface area, children were grouped into TLV >= 50 group and TLV < 50 group and the associations with perinatal-neonatal factors were analyzed. Results: Of the 28 children (mean age, 6.2 +/- 0.2 years) with left-sided CDH, 7 (25%) had abnormal pulmonary function, of whom 6 (87%) showed restrictive patterns. All pulmonary functions except FEF25-75% were worse than those in matched healthy control group. Worse pulmonary function was significantly associated with small head and abdominal circumferences at birth. The mean TLV was 1339.1 +/- 363.9 mL and LLV/TLV was 47.9 +/- 2.5 mL. Children with abnormal pulmonary function were more likely to have smaller lung volumes. In multivariate analysis, abdominal circumference at birth was significantly associated with abnormal lung volume. Conclusions: A quarter of children with repaired CDH showed abnormal pulmonary function. Small abdominal circumference at birth was associated with abnormal pulmonary function and lower TLV.
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页数:7
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