Catalytic Enantioselective Addition of Organozirconium Reagents to Aldehydes

被引：4

作者：

Sola, Ricard ^{[1
]}

Veguillas, Marcos ^{[1
]}

Gonzalez-Soria, Maria Jose ^{[1
]}

Carter, Nicholas ^{[1
]}

Fernandez-Ibanez, M. Angeles ^{[2
]}

Macia, Beatriz ^{[1
]}

机构：

[1] Manchester Metropolitan Univ, Div Chem & Environm Sci, Oxford Rd, Manchester M1 5GD, Lancs, England

[2] Vant Hoff Inst Mol Sci, Sci Pk 904, NL-1090 GS Amsterdam, Netherlands

来源：

MOLECULES | 2018年 / 23卷 / 04期

基金：

英国工程与自然科学研究理事会;

关键词：

alkenes; asymmetric catalysis; titanium; addition to aldehydes; Schwartz reagent; ASYMMETRIC CONJUGATE ADDITION; GRIGNARD-REAGENTS; ORGANIC-SYNTHESIS; ALKYLZIRCONIUM REAGENTS; CARBONYL-COMPOUNDS; HYDROZIRCONATION-TRANSMETALATION; ORGANOZINC ADDITIONS; ALIPHATIC-ALDEHYDES; QUATERNARY CENTERS; ALLYLIC ALCOHOLS;

D O I：

10.3390/molecules23040961

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A catalytic enantioselective addition reaction of alkylzirconium species to aromatic aldehydes is reported. The reaction, facilitated by a chiral nonracemic diol ligand complex with Ti(OiPr)(4), proceeds under mild and convenient conditions, and no premade organometallic reagents are required since the alkylzirconium nucleophiles are generated in situ by hydrozirconation of alkenes with the Schwartz reagent. The methodology is compatible with functionalized nucleophiles and a broad range of aromatic aldehydes.

引用

页数：12

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