Dopamine transporter and D2 receptor binding densities in mice prone or resistant to chronic high fat diet-induced obesity

被引：105

作者：

Huang, Xu-Feng

Zavitsanou, Katerina

Huang, Xin

Yu, Yinghua

Wang, HongQin

Chen, Feng

Lawrence, Andrew J.

Deng, Chao ^{[1
]}

机构：

[1] Univ Wollongong, Sch Hlth Sci, Dept Biomed Sci, Wollongong, NSW 2522, Australia

[2] NISAD, Darlinghurst, NSW 2010, Australia

[3] Univ Melbourne, Howard Florey Inst Expt Physiol & Med, Melbourne, Vic 3010, Australia

来源：

BEHAVIOURAL BRAIN RESEARCH | 2006年 / 175卷 / 02期

基金：

英国医学研究理事会;

关键词：

obesity; dopamine transporter; D-2; receptor; high-fat diet;

D O I：

10.1016/j.bbr.2006.08.034

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

This study examined the density of dopamine transporter (DAT) and D, receptors in the brains of chronic high-fat diet-induced obese (cDIO), obese-resistant (cDR) and low-fat-fed (LF) control mice. Significantly decreased DAT densities were observed in cDR mice compared to cDIO and LF mice, primarily in the nucleus accumbens, striatal and hypothalamic regions. D, receptor density was significantly lower in the rostral part of caudate putamen in cDIO mice compared to cDR and LF mice. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：415 / 419

页数：5

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