Labrenzbactin from a coral-associated bacterium Labrenzia sp.

被引：35

作者：

Sharma, Amit Raj ^{[1
,2
]}

Zhou, Tao ^{[1
,2
]}

Harunari, Enjuro ^{[1
,2
]}

Oku, Naoya ^{[1
,2
]}

Trianto, Agus ^{[3
]}

Igarashi, Yasuhiro ^{[1
,2
]}

机构：

[1] Toyama Prefectural Univ, Biotechnol Res Ctr, 5180 Kurokawa, Imizu, Toyama 9390398, Japan

[2] Toyama Prefectural Univ, Dept Biotechnol, 5180 Kurokawa, Imizu, Toyama 9390398, Japan

[3] Diponegoro Univ, Fac Fisheries & Marine Sci, Tembalang Campus,St Prof Soedarto, Sh Semarang 50275, Central Java, Indonesia

来源：

JOURNAL OF ANTIBIOTICS | 2019年 / 72卷 / 08期

基金：

日本学术振兴会;

关键词：

SP NOV; SIDEROPHORE;

D O I：

10.1038/s41429-019-0192-x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new catecholate-containing siderophore, labrenzbactin (1), was isolated from the fermentation broth of a coral-associated bacterium Labrenzia sp. The structure and absolute configuration of 1 was determined by spectroscopic methods and Marfey's analysis. Overall, 1 showed antimicrobial activity against Ralstonia solanacearum SUPP1541 and Micrococcus luteus ATCC9341 with MIC values of 25 and 50 mu g ml(-1), respectively, and cytotoxicity against P388 murine leukemia cells with an IC50 of 13 mu M.

引用

页码：634 / 639

页数：6

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