Age-related enzyme activity in different genotypes of alcohol dehydrogenase (ADH) in Drosophila melanogaster

被引：5

作者：

Bozcuk, AN ^{[1
]}

Sumer, S

Ozsoy, ED

Arisoy, M

机构：

[1] Hacettepe Univ, Dept Biol, TR-06532 Ankara, Turkey

[2] Ankara Univ, Dept Basic Hlth Sci, Hlth Educ Fac, TR-06100 Ankara, Turkey

来源：

BIOGERONTOLOGY | 2004年 / 5卷 / 04期

关键词：

ageing; alcohol Dehydrogenase; drosophila melanogaster; enzyme activity;

D O I：

10.1023/B:BGEN.0000038025.07744.75

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Ageing is a complex phenomenon with possibly a multitude of contributions from many genes. In our study, we tested the degree of contribution of alcohol dehydrogenase (Adh) polymorphism (as specific enzyme activities) to ageing in Drosophila melanogaster. Our results indicate an overdominance of FS genotypes on ageing flies, with the two homozygotes, i.e., FF and SS, having significantly lower mean longevities. However, that kind of life-span-genotype relationship was not detected when the genotypes were observed for the immediate function of the Adh locus, ADH enzyme activity in which mean ADH-FF activity was the highest as compared to those of ADH-FS and ADH-SS. This irrelevancy of the ADH enzyme function to ageing, with an obvious overdominance effect of Adh locus, is discussed considering Adh's known relation to other life history traits.

引用

页码：243 / 247

页数：5

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