Natural Carriers for siRNA Delivery

被引:10
|
作者
Karunaratne, D. Nedra [1 ]
Jafari, Mousa [2 ]
Ranatunga, R. J. K. Udayana [1 ]
Siriwardhana, Asitha [3 ]
机构
[1] Univ Peradeniya, Dept Chem, Peradeniya, Sri Lanka
[2] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
[3] Sri Lanka Inst Nanotechnol, Mahenwatte, Homagama, Sri Lanka
关键词
siRNA delivery; natural polymeric carriers; polysaccharides; peptides; exosomes; CELL-PENETRATING PEPTIDE; SMALL INTERFERING RNA; CHITOSAN-DNA NANOPARTICLES; ENDOTHELIAL GROWTH-FACTOR; NONVIRAL GENE VECTORS; IN-VITRO; HYALURONIC-ACID; TRANSFECTION EFFICIENCY; TARGETED DELIVERY; MOLECULAR-WEIGHT;
D O I
10.2174/138161282131151013185528
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This review is based on carriers of natural origin such as polysaccharides, proteins, and cell derived entities which have been used for delivery of siRNA. To realize the therapeutic potential of a delivery system, the role of the carrier is of utmost importance. Historical aspects of viral vectors, the first carriers of genes are briefly outlined. Chitosan, one of the extensively experimented carriers, alginates and other polysaccharides have shown success in siRNA delivery. Peptides of natural origin and mimics thereof have emerged as another versatile carrier. Exosomes and mini cells of cellular origin are the newest entrants to the area of siRNA delivery and probably the closest one can get to a natural carrier. In many of the carriers, modifications have provided better efficiency in delivery. The salient features of the carriers and their advantages and disadvantages are also reviewed.
引用
收藏
页码:4529 / 4540
页数:12
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