Aquaculture, like terrestrial farming, cannot achieve economic and sustainable production without high performing genetic stocks tailored to the conditions under which they are grown. It is essential, therefore, that aquaculture investment includes genetics and biotechnology to adapt marine livestock to the novel conditions of intensive aquaculture and to the demanding markets into which they are sold. The return on investment in well-structured breeding programmes can be very high, and significant performance and economic gains have been demonstrated in multiple species. Many factors must be considered in designing a genetic improvement programme, including the reproductive biology of the species and the identification of realistic and commercially relevant breeding goals based on the resources and facilities available. This paper reviews the options available to aquaculturists and provides examples of how these are being applied to six aquaculture species in New Zealand: king salmon, hapuku, kingfish, Greenshell (TM) mussels, Pacific oysters and paua (abalone).