Sodium-Glucose Cotransporter-2 Inhibitors, Reverse J-Curve Pattern, and Mortality in Heart Failure

被引：2
|
作者：
Imprialos, Konstantinos [1 ,2 ]
Stavropoulos, Konstantinos [1 ,2 ]
Papademetriou, Vasilios [1 ,2 ]
机构：
[1] VAMC, 50 Irving St, Washington, DC 20422 USA
[2] Georgetown Univ, 50 Irving St, Washington, DC 20422 USA
来源：
HEART FAILURE CLINICS | 2019年 / 15卷 / 04期
关键词：
SGLT-2; inhibitors; Cardiovascular events; Heart failure; Reverse J- curve; Mortality; TYPE-2; DIABETES-MELLITUS; ADD-ON THERAPY; LONG-TERM EFFICACY; METFORMIN PLUS SULFONYLUREA; AMBULATORY BLOOD-PRESSURE; IMPROVES GLYCEMIC CONTROL; DOUBLE-BLIND; JAPANESE PATIENTS; CARDIOVASCULAR OUTCOMES; HYPERTENSIVE PATIENTS;
D O I：
10.1016/j.hfc.2019.06.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The prevalence of diabetes mellitus and heart failure is increasing. The novel sodium-glucose cotransporter-2 (SGLT2) inhibitors offer multidimensional ameliorating effects on cardiovascular and heart failure risk factors. Several studies have assessed the impact on cardiovascular events, with data suggesting beneficial effects on cardiovascular events in high-risk patients with diabetes in patients with heart failure. The reverse J-curve pattern between blood pressure levels and mortality has emerged as an important topic in the field of heart failure. There is no significant evidence to propose any potential effect of SGLT2 inhibitors on the J-shape-suggested mortality in patients with heart failure.
引用
收藏
页码：519 / +
页数：13
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