Investigation of a novel diamine based chiral auxiliary in the asymmetric alkylation of ketones

被引：7

作者：

Clarke, Sarah L.

McSweeney, Christina M.

McGlacken, Gerard P. ^{[1
]}

机构：

[1] Natl Univ Ireland Univ Coll Cork, Analyt & Biol Chem Res Facil, Cork, Ireland

来源：

TETRAHEDRON-ASYMMETRY | 2014年 / 25卷 / 04期

基金：

爱尔兰科学基金会;

关键词：

IONOPHORE ANTIBIOTIC X-14547A; CYCLIC CARBAMATE HYDRAZONES; ALPHA-ALKYLATION; ACYCLIC KETONES; PROLINE; ALPHA; ALPHA-BISALKYLATION; TETRAHYDROPYRAN; DERIVATIVES; EFFICIENT;

D O I：

10.1016/j.tetasy.2014.01.006

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A novel chiral auxiliary containing a pyrrolidine ring has been utilised in the preparation of various chiral ketones with good to excellent enantioselectivities (up to 92%). It has been successfully employed in aldol and Michael reactions giving moderate to high selectivity. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：356 / 361

页数：6

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