Investigation of a novel diamine based chiral auxiliary in the asymmetric alkylation of ketones

被引：7
|
作者：
Clarke, Sarah L.
McSweeney, Christina M.
McGlacken, Gerard P. [1 ]
机构：
[1] Natl Univ Ireland Univ Coll Cork, Analyt & Biol Chem Res Facil, Cork, Ireland
来源：
TETRAHEDRON-ASYMMETRY | 2014年 / 25卷 / 04期
基金：
爱尔兰科学基金会;
关键词：
IONOPHORE ANTIBIOTIC X-14547A; CYCLIC CARBAMATE HYDRAZONES; ALPHA-ALKYLATION; ACYCLIC KETONES; PROLINE; ALPHA; ALPHA-BISALKYLATION; TETRAHYDROPYRAN; DERIVATIVES; EFFICIENT;
D O I：
10.1016/j.tetasy.2014.01.006
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A novel chiral auxiliary containing a pyrrolidine ring has been utilised in the preparation of various chiral ketones with good to excellent enantioselectivities (up to 92%). It has been successfully employed in aldol and Michael reactions giving moderate to high selectivity. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：356 / 361
页数：6
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