Terahertz Spectroscopic Diagnosis and Sub-wavelength Imaging of Myelin Deficit Monkey Brain with Chemometric Techniques

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作者
Zhu, Li-Guo [1 ,2 ]
Zou, Yi [1 ]
Li, Jiang [1 ,2 ]
Cui, Yiyuan [3 ]
Du, Liang-Hui [1 ,2 ]
Chen, Mina [3 ]
Zhao, Jianheng [1 ]
机构
[1] China Acad Engn Phys, Inst Fluid Phys, Interdisciplinary Lab Phys & Biomed, Mianyang 621900, Sichuan, Peoples R China
[2] China Acad Engn Phys, Microsyst & Terahertz Res Ctr, Mianyang 621900, Sichuan, Peoples R China
[3] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
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TM [电工技术]; TN [电子技术、通信技术];
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0808 ; 0809 ;
摘要
Myelin Deficit of the central nervous system leads to several severe diseases in human, but lack definitive diagnostic test. In this work, we proposed and performed terahertz spectroscopy and sub -wavelength imaging combined with chemometric techniques to discriminate and evaluate the severity of myelin deficit in and rhesus monkey brains. We demonstrated THz imaging with sub-100 tm spatial resolution of brain tissues. And our spectroscopy results well match with pathological analysis, indicating that THz is a quick, powerful, evolving tool for identification and evaluation in preclinical animals and potentially in para-clinical biopsy of humans.
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