Synthesis of 2,3-dihydro-1H-indazoles by Rh( III)-catalyzed C-H cleavage of arylhydrazines

被引：16
|
作者：
Yao, Jinzhong [1 ]
Feng, Ruokun [1 ]
Lin, Cong [1 ]
Liu, Zhanxiang [1 ]
Zhang, Yuhong [1 ,2 ]
机构：
[1] Zhejiang Univ, Dept Chem, ZJU NHU United R&D Ctr, Hangzhou 310027, Peoples R China
[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 29期
关键词：
N BOND FORMATION; EFFICIENT SYNTHESIS; CATALYZED SYNTHESIS; FUNCTIONALIZATION; HETEROCYCLES; INDAZOLES; ALKYNES; 1-ARYL-1H-INDAZOLES; CARBOXAMIDES; 1H-INDAZOLES;
D O I：
10.1039/c4ob00921e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A rhodium-catalyzed efficient method for the synthesis of 2,3-dihydro-1H-indazoles is described. The reaction of arylhydrazines with olefins results in the corresponding 2,3-dihydro 1H-indazoles with exclusive regioselectivity via C-H bond activation. The utility of the methodology is illustrated by a rapid synthesis of 1H-indazoles under mild reaction conditions in half an hour.
引用
收藏
页码：5469 / 5476
页数：8
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