New N-terminal prolyl-dipeptide derivatives as organocatalysts for direct asymmetric aldol reaction

被引：32

作者：

Zheng, Ji-Fu ^{[1
]}

Li, Yao-Xian ^{[1
]}

Zhang, Suo-Qin ^{[1
]}

Yang, Song-Tao ^{[1
]}

Wang, Xiao-Ming ^{[1
]}

Wang, Yong-Zhi ^{[1
]}

Bai, Jie ^{[1
]}

Liu, Fu-An ^{[1
]}

机构：

[1] Jilin Univ, Coll Chem, Changchun 130023, Peoples R China

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 44期

关键词：

organocatalyst; N-terminal prolyl-dipeptide derivatives; direct aldol reaction; asymmetric catalysis;

D O I：

10.1016/j.tetlet.2006.08.084

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of new N-terminal prolyl-dipeptide derivatives have been synthesized and evaluated as organocatalysts for the direct asymmetric aldol reaction of acetone with electron-deficient aromatic aldehydes. At room temperature, the presence of 10 mol % of catalysts 2 and 5 efficiently catalyzes the direct asymmetric aldol reaction to give the aldol adducts with modest to excellent enantiomeric excesses (ee) values, which are up to 96%. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：7793 / 7796

页数：4

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