LINC00473: A novel oncogenic long noncoding RNA in human cancers

被引：11

作者：

Li, Lingfeng ^{[1
,2
,3
,4
,5
]}

Zhang, Xu ^{[1
,2
,3
,4
,5
]}

Liu, Nian ^{[1
,2
,3
,4
,5
]}

Chen, Xiang ^{[1
,2
,3
,4
,5
]}

Peng, Cong ^{[1
,2
,3
,4
,5
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Dermatol, Xiangya Rd 87, Changsha 410008, Hunan, Peoples R China

[2] Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China

[3] Xiangya Hosp, Hunan Key Lab Skin Canc & Psoriasis, Changsha, Hunan, Peoples R China

[4] Cent South Univ, Xiangya Hosp, Hunan Engn Res Ctr Skin Hlth & Dis, Changsha, Hunan, Peoples R China

[5] Cent South Univ, Xiangya Clin Res Ctr Canc ImmunoTherapy, Changsha, Hunan, Peoples R China

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2021年 / 236卷 / 06期

基金：

中国国家自然科学基金;

关键词：

biomarker; cancer; LINC00473; long noncoding RNA; PANCREATIC-CANCER; POOR-PROGNOSIS; BREAST-CANCER; EPIDEMIOLOGY; CELLS; TRANSCRIPTION; STATISTICS; CARCINOMA; REVEAL;

D O I：

10.1002/jcp.30176

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Long noncoding RNAs (lncRNAs) have been found to play essential roles in the occurrence and development of multiple human cancers. Accumulating evidence has shown that LINC00473, an oncogenic lncRNA, is upregulated in various human malignancies and related to poor clinical outcomes. Besides, LINC00473 overexpression can promote cell proliferation, migration, and invasion through multiple potential mechanisms, indicating that it may serve as a novel prognostic biomarker and therapeutic target for human cancers. Here, we reviewed the biological functions, molecular mechanisms, and clinical implications of LINC00473 in human cancers.

引用

页码：4174 / 4183

页数：10

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