Oxidative Thioesterification of Alkenes Mediated by 1,3-Dibromo-5,5-dimethylhydantoin and DMSO for the Synthesis of α-Ketothioesters

被引：8
|
作者：
Hua, Jiawei [1 ]
Xu, Jiaqi [1 ]
Xu, Jia [1 ]
Zho, Bochao [1 ]
Zhang, Dong [1 ]
Yang, Zhao [2 ]
Fang, Zheng [1 ]
Guo, Kai [1 ,3 ]
机构：
[1] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, 30 Puzhu Rd S, Nanjing 211816, Jiangsu, Peoples R China
[2] China Pharmaceut Univ, Coll Engn, 24 Tongjiaxiang, Nanjing 210003, Jiangsu, Peoples R China
[3] Nanjing Tech Univ, State Key Lab Mat Oriented Chem Engn, 30 Puzhu Rd S, Nanjing 211816, Jiangsu, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 25期
基金：
中国国家自然科学基金;
关键词：
Alkenes; Oxidation; Synthetic methods; Thioesters; KETO THIOESTERS; DIMETHYL-SULFOXIDE; AMINO-KETONES; ESTERS; ROUTE; ACID;
D O I：
10.1002/ejoc.201900585
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and mild approach for the synthesis of alpha-ketothioesters via 1,3-Dibromo-5,5-dimethylhydantoin (DBH)/DMSO mediated oxidative thioesterification of alkenes has been developed. Various of alpha-ketothioesters products were produced in moderate to good yields under metal-free conditions. And this method features readily available starting materials and broad substrate scope. Moreover, a plausible mechanism was proposed based on the methyl bromide captured experiment.
引用
收藏
页码：4056 / 4060
页数：5
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