In vitro and in vivo studies on biodegradable CaMgZnSrYb high-entropy bulk metallic glass

被引:158
|
作者
Li, H. F. [1 ,2 ]
Xie, X. H. [3 ,4 ]
Zhao, K. [5 ]
Wang, Y. B. [1 ,2 ]
Zheng, Y. F. [1 ,2 ]
Wang, W. H. [5 ]
Qin, L. [3 ,6 ]
机构
[1] Peking Univ, State Key Lab Turbulence & Complex Syst, Beijing 100871, Peoples R China
[2] Peking Univ, Dept Mat Sci & Engn, Coll Engn, Beijing 100871, Peoples R China
[3] Chinese Univ Hong Kong, Dept Orthopaed & Traumatol, Shatin, Hong Kong, Peoples R China
[4] Soochow Univ, Affiliated Hosp 1, Dept Orthoped, Suzhou 215006, Peoples R China
[5] Chinese Acad Sci, Inst Phys, Beijing 100190, Peoples R China
[6] Chinese Acad Sci, Translat Med Res & Dev Ctr, Inst Biomed & Hlth Engn, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
基金
中国国家自然科学基金;
关键词
Ca20Mg20Zn20Sr20Yb20; alloy; High-entropy alloys; Bulk metallic glasses; Biodegradable metals; Bone; MECHANICAL-PROPERTIES; STRONTIUM RANELATE; MAGNESIUM ALLOYS; DUAL-MODE; CORROSION; MICROSTRUCTURE; CYTOTOXICITY; BEHAVIOR; CA; BIOMATERIALS;
D O I
10.1016/j.actbio.2013.01.029
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
In order to enhance the corrosion resistance of the Ca65Mg15Zn20 bulk metallic glass, which has too fast a degradation rate for biomedical applications, we fabricated the Ca20Mg20Zn20Sr20Yb20 high-entropy bulk metallic glass because of the unique properties of high-entropy alloys. Our results showed that the mechanical properties and corrosion behavior were enhanced. The in vitro tests showed that the Ca20Mg20Zn20Sr20Yb20 high-entropy bulk metallic glass could stimulate the proliferation and differentiation of cultured osteoblasts. The in vivo animal tests showed that the Ca20Mg20Zn20Sr20Yb20 high-entropy bulk metallic glass did not show any obvious degradation after 4 weeks of implantation, and they can promote osteogenesis and new bone formation after 2 weeks of implantation. The improved mechanical properties and corrosion behavior can be attributed to the different chemical composition as well as the formation of a unique high-entropy atomic structure with a maximum degree of disorder. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:8561 / 8573
页数:13
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