Mast cell production and response to IL-4 and IL-13

被引：146
|
作者：
McLeod, Jamie J. A. [1 ]
Baker, Bianca [1 ]
Ryan, John J. [1 ]
机构：
[1] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA
来源：
CYTOKINE | 2015年 / 75卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Mast cells; Interleukin-4; IL-4; Interleukin-13; IL-13; FC-EPSILON-RI; NECROSIS-FACTOR-ALPHA; GENE-EXPRESSION; CYTOKINE PRODUCTION; NUCLEAR-FACTOR; MESSENGER-RNA; STAT6; ISOFORM; CUTTING EDGE; FACTOR-I; C-KIT;
D O I：
10.1016/j.cyto.2015.05.019
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
IL-4 was identified as the first cytokine to be produced by mast cells and is responsible for promoting mast cell IL-13 production. IL-4 and IL-13 play a prominent role in stimulating and maintaining the allergic response. As closely related genes, IL-4 and IL-13 share a common receptor subunit, IL-4R alpha, necessary for signaling. Here we summarize the literature on mast cell activation associated with IL-4 and IL-13 production, including downstream signaling. We also describe the positive and negative roles each cytokine plays in mast cell immunity and detail the differences that exist between mouse and human mast cell responses to IL-4 and IL-13. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：57 / 61
页数：5
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