Dysregulation of Epigenetic Mechanisms of Gene Expression in the Pathologies of Hyperhomocysteinemia

被引:65
|
作者
Perla-Kajan, Joanna [1 ]
Jakubowski, Hieronim [1 ,2 ]
机构
[1] Poznan Univ Life Sci, Dept Biochem & Biotechnol, PL-60637 Poznan, Poland
[2] Rutgers New Jersey Med Sch, Dept Microbiol Biochem & Mol Genet, Int Ctr Publ Hlth, Newark, NJ 07103 USA
来源
关键词
hyperhomocysteinemia; DNA methylation; histone; homocysteine thiolactone; N-homocysteinylation; miRNA; epigenetic; atherosclerosis; Alzheimer's disease; gene expression; SMOOTH-MUSCLE-CELLS; S-ADENOSYLHOMOCYSTEINE HYDROLASE; MAMMALIAN DNA METHYLTRANSFERASES; ALZHEIMERS-DISEASE IMPLICATIONS; MODIFICATIONS BASIC MECHANISMS; PROTEIN N-HOMOCYSTEINYLATION; LEUKOCYTE TELOMERE LENGTH; CARDIAC-SPECIFIC DELETION; INDUCED OXIDATIVE STRESS; TRANSFER RNA-SYNTHETASE;
D O I
10.3390/ijms20133140
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Hyperhomocysteinemia (HHcy) exerts a wide range of biological effects and is associated with a number of diseases, including cardiovascular disease, dementia, neural tube defects, and cancer. Although mechanisms of HHcy toxicity are not fully uncovered, there has been a significant progress in their understanding. The picture emerging from the studies of homocysteine (Hcy) metabolism and pathophysiology is a complex one, as Hcy and its metabolites affect biomolecules and processes in a tissue- and sex-specific manner. Because of their connection to one carbon metabolism and editing mechanisms in protein biosynthesis, Hcy and its metabolites impair epigenetic control of gene expression mediated by DNA methylation, histone modifications, and non-coding RNA, which underlies the pathology of human disease. In this review we summarize the recent evidence showing that epigenetic dysregulation of gene expression, mediated by changes in DNA methylation and histone N-homocysteinylation, is a pathogenic consequence of HHcy in many human diseases. These findings provide new insights into the mechanisms of human disease induced by Hcy and its metabolites, and suggest therapeutic targets for the prevention and/or treatment.
引用
收藏
页数:40
相关论文
共 50 条
  • [1] The dysregulation of lncRNAs by epigenetic factors in human pathologies
    Zhang, Yanli
    Wang, Xiaocong
    Zhang, Chen
    Yi, Huanfa
    [J]. DRUG DISCOVERY TODAY, 2023, 28 (09)
  • [2] Epigenetic Dysregulation of Trophoblastic Gene Expression in Gestational Trophoblastic Disease
    Szabolcsi, Zoltan
    Demeter, Amanda
    Kiraly, Peter
    Balogh, Andrea
    Wilson, Melissa L.
    King, Jennifer R.
    Hetey, Szabolcs
    Gelencser, Zsolt
    Matsuo, Koji
    Hargitai, Beata
    Mhawech-Fauceglia, Paulette
    Hupuczi, Petronella
    Szilagyi, Andras
    Papp, Zoltan
    Roman, Lynda D.
    Cortessis, Victoria K.
    Than, Nandor Gabor
    [J]. BIOMEDICINES, 2021, 9 (12)
  • [3] EPIGENETIC MECHANISMS FOR TRANSCRIPTIONAL DYSREGULATION IN SCHIZOPHRENIA
    Tang, Bin
    Thomas, E.
    [J]. SCHIZOPHRENIA BULLETIN, 2009, 35 : 228 - 228
  • [4] Epigenetic Dysregulation of Virulence Gene Expression in Severe Plasmodium falciparum Malaria
    Merrick, Catherine J.
    Huttenhower, Curtis
    Buckee, Caroline
    Amambua-Ngwa, Alfred
    Gomez-Escobar, Natalia
    Walther, Michael
    Conway, David J.
    Duraisingh, Manoj T.
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2012, 205 (10): : 1593 - 1600
  • [5] A Brief Landscape of Epigenetic Mechanisms in Dental Pathologies
    [J]. Cytology and Genetics, 2022, 56 : 475 - 480
  • [6] A Brief Landscape of Epigenetic Mechanisms in Dental Pathologies
    Tynior, Wojciech
    Strzelczyk, Joanna Katarzyna
    [J]. CYTOLOGY AND GENETICS, 2022, 56 (05) : 475 - 480
  • [7] Epigenetic mechanisms that regulate antigen receptor gene expression
    Bergman, Y
    Fisher, A
    Cedar, H
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2003, 15 (02) : 176 - 181
  • [8] Epigenetic mechanisms of gene expression regulation in neurological diseases
    Gos, Monika
    [J]. ACTA NEUROBIOLOGIAE EXPERIMENTALIS, 2013, 73 (01) : 19 - 37
  • [9] Regulation of Gene Expression and Pain States by Epigenetic Mechanisms
    Geranton, Sandrine M.
    Tochiki, Keri K.
    [J]. MOLECULAR AND CELL BIOLOGY OF PAIN, 2015, 131 : 147 - 183
  • [10] EFFECT OF NATURAL POLYPHENOLS ON EPIGENETIC MECHANISMS OF GENE EXPRESSION
    Lewandowska, Patrycja
    Wozniak, Katarzyna
    [J]. POSTEPY BIOLOGII KOMORKI, 2017, 44 (02) : 213 - 225