Analysis of regulatory T cell subsets in the peripheral blood of immunoglobulin A nephropathy (IgAN) patients

被引：23
|
作者：
Yang, S. [1 ]
Chen, B. [1 ]
Shi, J. [1 ]
Chen, F. [1 ]
Zhang, J. [1 ]
Sun, Z. [1 ]
机构：
[1] Henan Univ, Huaihe Hosp, Dept Nephrol, Kaifeng, Peoples R China
来源：
GENETICS AND MOLECULAR RESEARCH | 2015年 / 14卷 / 04期
关键词：
Immunoglobulin A nephropathy; Regulatory T cells; Subset; TONSILS;
D O I：
10.4238/2015.October.29.28
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The aim of this study was to investigate the clinical significance of regulatory T cells (Tregs) and its subsets in immunoglobulin A nephropathy (IgAN) patients. Peripheral blood samples of 20 IgAN patients and 20 healthy individuals of similar ages were analyzed. Levels of Tregs and its subsets, namely nTregs and iTregs, were analyzed using flow cytometry. The number of Tregs in IgAN patients was significantly lower than that in the healthy controls. While significant reduction in iTregs primarily contributed to this effect (P < 0.01), nTreg levels did not significantly change (P > 0.05). The levels of serum IL-17, IL-10 and TGF-beta were detected by ELISA method. The levels of IL-10 and TGF-beta in IgAN patients were lower (P < 0.05), whereas those of IL-17 in the IgAN group were higher (P < 0.05) than those in the controls. In conclusion, the change in Tregs count in the peripheral blood of IgAN patients is mainly caused by the reduction in iTregs, suggesting a substantial role in the prognosis and treatment of IgAN.
引用
收藏
页码：14088 / 14092
页数：5
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